TyK2-IN-2 aminomethyl CBL0137 hydrochloride causes a greater

CBL0137 hydrochloride causes a greater reduction in the number of colonies formed of not only MiaPaCa-2 cells when combines with gemcitabine

51-bis(3-guanidinopropyl)-24-(4-hydroxybenzyl)-9

6R)-2-(4-chloro-3-{[4-(2-cyclopropoxyethoxy)phenyl]methyl}phenyl)-6-(hydroxymethyl)oxane-3

Smiles: NC1N=CN=C2C=1C(=CN2C1CCCC1)C1C=CC(=CC=1)OC1C=CC=CC=1

TyK2-IN-2 aminomethyl CBL0137 hydrochloride causes a greaterTyK2 IN 2 (Compoud 18) is a potent and selective TYK2 inhibitor with IC50s of 7 nM, 0. 1 M and 0. 05 M for TYK2 JH2, IL 23 and IFN, respectively. TyK2 IN 2 also inhibits phosphodiesterase 4 (PDE4) with an IC50 of 62 nM. TyK2 IN 2 can be used for the research of inflammatory and autoimmune diseases. Product information CAS Number: 2098466 94 3 Molecular Weight: 310. 35 Formula: C16H18N6O Chemical Name: 6 [(3,5 dimethylphenyl)amino] 8